Helmadol (Albendazole)
COMPOSITION
Each film coated tablet contains albendazole 200
mg.
THERAPEUTIC INDICATIONS
Helmadol is a highly effective antiparasitic
agent of a polyvalent action; the majority of helminthiases may be treated with
this agent:
- nematodosis:
Ascariasis, disease-producing factor – nematode helminth Ascaris lumbricoides;
Trichocefales (whipworm), disease-producing factor – nematode helminth
Trichocephalus trichiurus;
Enterobiasis (pinworms), disease-producing factor – nematode helminth Enterobius
vermicularis;
Ankylostomiasis, disease-producing factors – Ancylostoma duodenale and Necator
americanus; Trichinella spiralis trichinosis, disease-producing factors – meat
porkworms;
Toxocariasis, disease-producing factor – Toxocara canis, dog parasite;
Strogiloidosis (dwarf threadworm), disease-producing factor – nematode helminth
Strongiloides stercoralis,
And also mixed invasions;
- Tissue cestodosis:
Cysticercosis;
Hydatid disease of liver, lungs, peritoneum, caused by larval stage of dog
tapeworm (Echinococcus granulosus),
Also the drug is applied as an additive agent in surgical treatment of alveolar
echinococcosis.
CONTRAINDICATIONS
- Hypersensitivity to any drug ingredients and
other derivatives of benzimidazole;
- Eye retina pathology;
- Pregnancy;
- Lactation (breast feeding).
ADVERSE EFFECTS
Effects on digestive system: abdominal pains,
nausea, vomiting.
Effects on cardiovascular system: elevation of blood pressure.
Effects on central nervous system: headache and dizziness.
Effects on urinary excretion system: changes of indices of renal function (acute
renal impairment).
Dermatologic reactions: itching, skin eruption and other allergic reactions.
DOSAGE AND ADMINISTRATION
Oral administration during or after meal intake.
Special preparation and diet is not required.
Choose a drug formulation individually depending on convenience of a drug and
tolerance of its compounds.
Determine a dose individually depending on invasion type, patient's body weight.
The maximum daily dose is 800 mg.
Ascaridiasis, trichocefales: for patients with body weight of 60 kg and more –
400 mg daily as a single dose or 200 mg 2 times a day; for patients with body
weight less than 60 kg – 15 mg/kg daily divided into two doses.
Enterobiasis: 5 mg/kg of body weight as a single dose. Repeat the scheme in 14
days.
Strongyloidosis, ankylostomiasis 10 mg/kg of body weight daily within 3 days.
Repeat the scheme in 14 days.
Trichinosis: 10 mg/kg of body weight daily divided into two doses within 7-10
days.
Toxocariasis. 10 mg/kg of body weight daily divided into two doses after meal
within 10 days. Repeat the scheme in 14 days or a month.
Hydatid echinococcosis. Treatment is possible if laboratory indices are within
limits. 10 mg/kg of body weight daily divided into two or three doses. Therapy
course is 3 cycles of 28 days with 14 day's interval.
Cysticercosis: 15 mg/kg of body weight daily divided into three doses. The
therapy course is 28-30 days.
DRUG INTERACTIONS
Dexamethasone and cimetidine increases blood
albendazole sulfoxide concentration.
PREGNANCY AND LACTATION
Helmadol is contraindicated during pregnancy and
lactation (breast-feeding).
MANUFACTURED FORM
2 film coated tablets in blister. 1 blister with
leaflet in carton box.
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